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| Figure 1. SIH |
Back in March, I began my 2026 Search for Interesting Hollywood Aliens by mentioning the film "Project Hail Mary" which was being advertised as depicting an "impossible scientific mystery". My first question is: does this movie provides us with a couple of hours of entertainment featuring an interesting alien? Bonus: is there an interesting microbe?
Sun Fiction. Back in 2022 I commented on the 1942 story "Proof" by Hal Clement. That story featured life-forms with a "matrix of electrons" that could convert stellar radiation into neutrons. Not only does the "skin" of these Sun creatures (the hero of the story is named "Kron") surround a core of neutronium (held in the creature's "nucleus"), but the "skin" can convert energy from the environment into new "particles of neutronium" that are then guided by magnetic fields towards the body core. I'm a huge skeptic when it comes to imaginary life-forms that live in or on a star, particularly if they are biological life-forms composed of cells.
In "Project Hail Mary", we are apparently being asked to believe that some cells are able to fly through outer space and gather around stars and store lots of energy as neutrinos. Maybe all of this fantasy biology is explained in the book, but in the film, people just talk fast when "explaining" this alien biology and hope that we will be distracted by the one other alien life-form that is in the movie: Rocky, an Eridian.Alternate Technologies. We are told that the technologically-advanced Eridians are "unaware of relativity". A memorable example of this kind of "technology blind spot" is in Clifford D. Simak's story "The Big Front Yard" where there are aliens who never thought to invent paint. I find it hard to believe that any alien with technology advanced enough to be traveling around the galaxy would either never have invented paint or never noticed relativity.
Thanks for the memories. I don't mind when futuristic technologies come bundled with with constraints and costs. In "Project Hail Mary", we are told that an incredibly great source of energy is available (the conveniently wrapped neutrinos in the space microbes), but we can't store ten years worth of food in our interstellar spaceship. Would sleeping for three years cause selective and temporary loss of some memories? I don't know, but I do know that this overly long movie could have been improved by not including this issue in the film.
Rocky and hoodwinkle show. The Eridians might have skipped class on the day when relativity was discussed, but they do have some cool technology. I can't stop myself from imagining that they might have advanced nanotechnology and access to hierions. Imagine a type of hierion that could be made into a composite with xenon, forming a metallic substance that is both easy to form into useful shapes, yet is also very strong.
The Rocky character in "Project Hail Mary" is amusing for about 30 minutes. Not sure I'd want to spend the rest of my life teaching young Eridians. Shouldn't someone be out trying to prevent more habitable planets from having their solar energy supply blocked? Maybe that is for the sequel.
Disclosure Day. Apparently there actually is an alien on screen at the end of "Disclosure Day", but the movie seems to actually be about some absurd corporate/government conspiracy like in The X-Files. While searching for "Disclosure Day." I saw a marketing trick for the film, a red cardinal flying across the search results page. Good to see Google has endless ways of making $$$ from corporations even while providing search engine results for a movie that claims to be about aliens helping to take down a SuperSecret™ conspiracy by some mysterious corporate entity.![]() |
| Figure 2. Image source. |
Microbe Search. I decided to search for old science fiction stories about weird microbes. Before taking a deep dive into the ISFDB, I'll mention two of the earliest science fiction stories featuring microbes that I read or saw on television: "Surface Tension" and "Fantastic Voyage". In James Blish's "Surface Tension", Blish had the audacious idea of a character who was an intelligent paramecium which deeply offended my 12-year-old self's view of the universe. "Fantastic Voyage" was only memorable for a scene in which Raquel Welch gets encased in white blood cells which then have to be pealed off of her curvaceous body by three groping men. Related Reading: see the stories by Arthur Porges, see also "Un homme chez les microbes" by Maurice Renard which features a man who is shrunk.
The first candidate microbe story I came across at the ISFDB was "A Major Microbe" by W. L. Alden, but that story is not science fiction and is not actually about a microbe. The same can be said for "The Princess and the Microbe" by Margaret Sherwood.
Weird title. I discovered that the French translation of "Needle" was titled "Le microbe détective". My best guess is that misleading title was used because there was an existing sub-genre of crime fiction about using microbes as murder weapons.
At "First fictional lab-created plague" it says that "Professor Bakermann's Microbe" (published in 1890) is set in 1935, where the microbes causing all known diseases have been studied. The wacky Professor Bakermann cooks up a new disease microbe that can't be stopped; it is resistant to all known drugs and treatments. I've never read the story, but Google's AI Mode agent likens it to Mary Shelley's Frankenstein. The story was first published as a serial in La Science Illustrée (see Figure 2).
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I've skimmed through "The Master of the Microbe" (1926) which seems incredibly long and muddled, something like a James Bond movie with an evil character threatening the world. In the story there is a "crimson carnet", the "silver cylindar", assorted uncles, detectives and doctors along with several women to chase around after while a man-made plague spreads. The microbiology in "The Master of the Microbe" seems diseased and confused, although Google's AI Mode agent assured me that Robert Service had written into the story the idea that a pathogenic bacterium could be countered by a bacteriophage. However, the word "virus" appears only once in the story, in a sentence that makes no sense and we are told that Professor Hermann Krug (the discoverer of the plague bacterium) is a "well-known savant of Swiss origin, and considered in University circles to be a supreme authority on Micrology." It seems clear that Service knew nothing about microbes or microbiology. I could not sort out what is going on in the story with the dude named "Sinistra" who was apparently an "alias of Maximus Quin", not to be confused with "Cyrus Quin". However, I am still confused, but not interested enough to actually read the story.
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A Strange Case. Not much is known about John Geo. E. Leech, author of "The Microbe of Love" published in Pearson's Magazine, October 1902. This is a joke story in which a "bacillus" is found that causes people to experience the pangs of "love sickness". The discoverer hopes to make big $$$ by selling an antidote, but he falls in love before he can devise the antidote. Related Reading: "Mate in Two Moves", published in the May 1954 issue of Galaxy Science Fiction.
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I skimmed "The Bacillus of Beauty" by Harriet Stark (1900). It is impossible for me to say that "The Bacillus of Beauty" is about a microbe. Readers are told that a woman's appearance is transformed by a bacillus, but there is no reason to believe it. The story seems like a fantasy where a magic spell does the transformation.
"The Bacillus of Conscience" (1905) by Wilbur Dick Nesbit (Wikipedia) is pretty funny. It inspired a song titled "B. Conscience". In "The Bacillus of Conscience", Nesbit followed a standard Sci Fi formula with a scientist, his daughter and a man who is love with the daughter, Constance. Lyrics:
[Verse 1]
I must offer some comments
on the bacillus of conscience
but refer to it as B. conscience
“B is for Busy,” giggled Constance
Busy B stands before our conscience
shall I confess to giant nonsense?
Small it is, in the strong sense
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| "B. Conscience" |
It’s a tiny little bug with a heavy load
Screaming down a dusty, lonesome road
If you got a secret, it’s gonna find a way
To make you spit it out by the end of the day
(B. Conscience, honey)
(It’s a heavy price you pay)
[Verse 2]
In the bacterial inventory
was it new or a priori?
Obtained from a criminal gory
it made just a little history
For Professor Bindham's glory
and to be a science fiction story
B. conscience left the laboratory
[Bridge]
Is a man still a man if the truth is forced
Like a dry creek bed or a dying horse?
It ain't a choice when it’s under your skin
Just a fever burning out the original sin
(Burning it out)
(Let the truth walk in)
[Verse 3]
A microbe from 1905, I confess it
discovered by Wilbur D. Nesbit
It began with a crime committed
Bacillus conscience with no respite
made the criminal confessed to it
We need it in 2026 just a bit
to use it on our president[Final Chorus]
Oh, it’s a tiny little bug with a heavy load
It don't care about the laws or the code
If you got a secret, it’s gonna find a way
To make you scream it out by the end of the day
(B. Conscience, honey)
(It’s the only way)
[Outro]
Just a little drop for the man at the top
Once the valve is open it’s never gonna stop
(B. Conscience)
(Sinking in)
Yeah, it’s catching
Watch your mouth now
(B. Conscience)
It’s catching
(Catching)
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| Figure 3. Interior art by Leo Morey |
Wells, Wells. In "The Stolen Bacillus" (1894) by H. G. Wells. An anarchist threatens the London water supply with cholera stolen from the laboratory of a bacteriologist. Disaster is averted when we learn that the stolen bacterial strain is not cholera, but rather a microbe that turns the skin blue... and only the anarchist is infected.
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| Figure 4. Interior art by George T. Tobin. |
In "Dr. Cox's Discovery" by Herbert D. Ward (1903), the second paragraph includes this sentence: "What will not the bacillus be responsible for next?" Dr. Cox wants to isolate a "microbiote" that can cause death from old age. Here is another line from the story: "Nothing pleases an Englishman more than a spice of adventure in which the superstitions of an inferior race are trampled upon."
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| Figure 5. Imaginary cover art by Flow. (original cover) |
Eventually, Dr. Cox finds something that that acts like a fountain of youth. In this fantasy story, Ward could not be bothered to provide a coherent explanation, just the hint that it involved test tubes. Then there is a contrived "explanation" for why Dr. Cox throws away the "fountain of youth". The End. As hinted at in Figure 4, much of the story revolves around a weird love triangle. The only two test creatures for the "fountain of youth" are a dog and the mother (the brunette in Figure 4) of Dr. Cox's girl friend (the blond in Figure 4). After dear mom dies, Dr. Cox apparently gets to live happily ever after with the daughter.
Another "fountain of youth" story was "The Blue Germ" (1918) which is available via Google Books. I tried to read "The Blue Germ" but I soon began skimming and then at page 38 is: "The bacillus was ultra-microscopical. It could not be seen even with the highest power, under the microscope". Other people have interpreted this as indicating that the "fountain of youth" was a virus, but the term 'virus' does not appear in the story. I suspect there is nothing resembling science fiction in this novel.
"Max Hensig: Bacteriologist and Murderer" (1907) by Algernon Blackwood is long, tedious and contrived. The story seemingly includes an attempt to depict a man getting so drunk that all the alcohol in his body will serve as protection against bacterial infection. The imaginary cover art for "Max Hensig: Bacteriologist and Murderer" (see Figure 5) was made using this text prompt: "A full color movie still showing two men in a prison cell, the accused criminal is a light-haired stripling with blue eyes and drooping mustache, that rare type of deliberate murderer, cold-blooded and calculating, who kills for a song, delights in killing, and gives its whole intellect to the consideration of each detail, glorying in evading detection and reveling in the notoriety of the trial, if caught. At first he had answered reluctantly, but then the young murderer warmed up and became enthusiastic with a sort of cold intellectual enthusiasm, till at last he held forth like a lecturer, pacing his cell, gesticulating, explaining with admirable exposition how easy murder could be to a man who knew his business. And he did know his business! The reporter watched in dismay and horror."
Heart of Gold. "The Golden Rat" by Alexander Harvey (1913) is one of the most unique stories that I have found while investigating old stories that involve microbes. It is a fantasy story with only very minor science fictional microbiology elements. The narrator (a psychoanalyst) imagines that he was infected by golden bacterium from a golden pet rat (named 'Philander') that turns his blood into gold. "The Golden Rat" is also a strange "love story", in that the golden rat eventually leads the narrator to realize that one of his patients, Miss Lancaster, is in love with him."Strangers on Paper" is an episode of "Murdoch Mysteries" that was first shown about six months ago (January 2026), but I only just watched it. In one of the silliest "mad scientist" stories ever, the plot of "Strangers on Paper" includes an angry scientist who tries to put Staphylococcus aureus into the water supply in revenge for loss of funding for research on Staphylococcus aureus. Related Reading: Amerithrax.
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| Figure 6. Interior artwork by Leo Morey |
Great Northern Protist. "Nœkken of Norway" by Bob Olsen (1934) provides an account of a close encounter with a giant amoeba that lives in a lake in Norway. Readers are told that if an endocrine problem in the pituitary gland can make for a giant human then why not an amoeba that just keeps growing? As shown in Figure 6, the giant amoeba is usually found in water, but when it gets hungry it will go onto shore and grab yummy people for a snack. this It turns out that mistletoe is the giant amoeba's kryptonite. By the way, Wikipedia's article on kryptonite has more references than the article about mistletoe.
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| Figure 7. Interior artwork by Malcolm Smith |
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The first mention of microbes in this blog was in 2012 when I was speculating about the everyday microbial horrors that might have motivated some of the horror elements in Frankenstein. I wrote, "Our species is in the middle of figuring out the world we live in. In the past, millions were mysteriously struck down by infectious diseases and it was all too easy to adopt an attitude of desperation and helplessness when we had no tools for observing microbes. Now the science of microbiology routinely makes it possible for us to understand, treat and prevent microbial diseases." Even a story as goofy as "Amoeba 'Roid" can be viewed as a human reaction to the never ending conflict between humans and microbes.
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| Foundations of Eternity |
My story Foundations of Eternity included the idea that Neanderthals were driven to extinction because they were susceptible to microbial diseases that were spread by modern humans. When Manny the bumpha takes an interest in the unusual behavior of the Neanderthals, she Intervenes by secretly providing Neanderthals with key resistance genes.
Back in 2015, I introduced the idea that in a past Reality, Earth might have been intentionally pushed towards having high green house gas levels. Such a Reality could be used as a laboratory for "developing microbes that could efficiently metabolize methane and trap atmospheric carbon dioxide in marine sediments". The climate change mitigation methods developed by humans in such a Reality might then be re-used in another Reality to prevent global warming. In "The Hierozyme Intervention", I explore this strategy. How can a microbial solution to global warming be brought into a Reality without alerting the pek Overseer of Earth to such an alien Intervention? I'm currently writing Chapter 10 of "The Hierozyme Intervention" in which Marda is trying to gain access to Eddy's Reality Viewer. Anthony has been moved out of Casanay and his replacement, Ada B. Catalana, has just been hired. Systolina suspects that Ada is a secret agent for Manny the bumpha, but how can Ada be used to give Marda access to the Reality Viewer that is hidden inside Eddy's computer?
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For "The Hierozyme Intervention", I'm still deciding on exactly what Marda will be able to learn from past Realities by using Eddy's Reality Viewer. Possibly in the Ekcolir Reality, humans eventually engineered microbes by artificial evolution that can be "re-animated" by Marda in the Final Reality and combined with hidden hierozymes. However, it is not clear why the pek would fail to notice the deployment of hierozymes. Maybe after first allowing Tyhry to be punished for using hierozymes, the final solution deployed by Marda will involve zeptites that are not detected by the pek.
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| This image was made using Mystique VI by emden09 available under the CC BY-NC-SA 3.0. image source |
Back in 2022, I read a large number of old science fiction stories featuring doctors and some of those stories involved microbes. One of those stories by Murray Leinster featured a microbe called the "chlorophage" that not only ate chlorophyll and killed plants, but which also had an appetite for hemoglobin. I don't know if Leinster's story was inspiration for the Star Trek episode "Obsession", but maybe the "gaseous Di-Kironium creature" was actually some form of advanced nanotechnology, a kind of femtozoan.
Related Reading: Ooze & Liquid Life.
Related Music: Weird Swamp Protist.
Next: Chapter 10 of "The Hierozyme Intervention".
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